Faber argued there hasn't been enough change in these federal regulations in the decades following the FDA's approval of titanium dioxide – especially as others increasingly point to potential health consequences.

Nano-sized P25TiO₂NPs were kindly donated by Dr. Scaiano, Ottawa University (Canada). Riboflavin (vitamin B2) was from Sigma and ascorbic acid (vitamin C) and KBr (for IR pills) were from Cicarelli. Base cream for the animal experiments was purchased from Todo Droga and the LED panel was built ad hoc.

A European ban of titanium dioxide in food took effect in 2022, but it is still legal for use in food in the U.S.

According to the feedback of manufacturers, the new orders of mainstream factories maintain stable prices, and the new volume of the market after the holiday is limited. On the demand side, the terminal basically has batch replenishment before the festival, and the purchase intention of new orders is low; On the supply side, mainstream manufacturers normally produce and deliver goods, and the actual output of the industry is stable. Most factories quote a new price of 17,000 yuan/ton or more market negotiation range reference 16000-17200 yuan/ton, plastics and papermaking related downstream feedback part of the tight model price is higher. Recent titanium dioxide raw material prices are strong, titanium dioxide price support is more stable, comprehensive market factors, the current titanium dioxide market to maintain a stable price.

Titanium dioxide is an important chemical compound that is widely used in various applications, including paint, cosmetics, sunscreens, and food coloring. As the demand for this versatile substance continues to grow, the role of titanium dioxide manufacturers becomes crucial in ensuring a stable supply for industries around the world.

Scientists analyzed research that examined how titanium dioxide nanoparticles interact with the brain for a 2015 review published in Nanoscale Research Letters. The researchers wrote: “Once the TiO2 NPs are translocated into the central nervous system through [certain] pathways, they may accumulate in the brain regions. For their slow elimination rates, those NPs could remain in the brain zones for a long period, and the Ti contents would gradually increase with repeated exposure.” After reviewing dozens of studies, the scientists concluded: “Long-term or chronic exposure to TiO2 nanoparticles could potentially lead to the gradually increased Ti contents in the brain, which may eventually induce impairments on the neurons and glial cells and lead to CNS dysfunction as a consequence.”

The updated evaluation revises the outcome of EFSA’s previous assessment published in 2016, which highlighted the need for more research to fill data gaps.